Journal article
Comparative Transcriptomic Exploration Reveals Unique Molecular Adaptations of Neuropathogenic Trichobilharzia to Invade and Parasitize Its Avian Definitive Host
R Leontovyč, ND Young, PK Korhonen, RS Hall, P Tan, L Mikeš, M Kašný, P Horák, RB Gasser
Plos Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2016
Abstract
To date, most molecular investigations of schistosomatids have focused principally on blood flukes (schistosomes) of humans. Despite the clinical importance of cercarial dermatitis in humans caused by Trichobilharzia regenti and the serious neuropathologic disease that this parasite causes in its permissive avian hosts and accidental mammalian hosts, almost nothing is known about the molecular aspects of how this fluke invades its hosts, migrates in host tissues and how it interacts with its hosts’ immune system. Here, we explored selected aspects using a transcriptomic-bioinformatic approach. To do this, we sequenced, assembled and annotated the transcriptome representing two consecutive li..
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Awarded by Ministerstvo Školství, Mládeže a Tělovýchovy
Funding Acknowledgements
The study was financially supported by a grant from the Czech Science Foundation (http://gacr.cz/en/), (no. 13-29577S; P.H. et al.) and the Charles University in Prague (http://www.cuni.cz/UKEN-65.html), (PRVOUK P41, UNCE 204017 and SVV 260202/2015; P.H. et al.). Funding from the National Health and Medical Research Council (https://www.nhmrc.gov.au), (NHMRC) of Australia, the Australian Research Council and Melbourne Water Corporation is gratefully acknowledged (R.B.G. et al.). This project was also supported by a Victorian Life Sciences Computation Initiative (https://www.vlsci.org.au) (VLSCI; grant number VR0007) on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government (R.B.G.). N.D.Y. holds an NHMRC Early Career Research Fellowship. P.K.K. is the recipient of a scholarship (STRAPA) from The University of Melbourne. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.